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KMID : 1189420220350040063
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2022 Volume.35 No. 4 p.63 ~ p.74
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Skin Moisturizing Activity of Unripe Apple(Immature Fruit of Malus pumila) in Mice
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Park Hye-Rim
Kim Jae-Kwang
Kim Jong-Dae
Ku Sae-Kwang
Jegal Kyung-Hwan
Lee Jae-Kyoung
Choi Beom-Rak
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Abstract
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Objectives : Skin aging is generally characterized by wrinkles, sagging, loss of elasticity roughness, pigmentation and dryness. This changes is caused by reducing the elements constituting the extracellular matrix contributing to the physiological properties of the skin, such as collagen fiber, elastic fiber, and hyaluronic acid. Adequate skin hydration is important to maintain normal skin function and reduce skin aging. The present study is objective to observe skin moisturizing effects of Unripe apple(UA, Immature fruit of Malus pumila Mill) in vivo and its underlying molecular mechanisms.
Methods : ICR mice were orally administerd UA(100, 200 and 400mg/kg/day) for 8 weeks, and skin water contents and the expression of transforming growth factor (TGF)-??1, ceramide, hyaluronan and collagen type I(COL1) were measured in dorsal back skin of the mice. Gene expression of hyaluronan synthase(HAS1, HAS2, HAS3), collagen synthase(COL1A1, COL1A2) and TGF-??1 were also determined by realtime RT-PCR.
Results : Skin water contents and the expression of TGF-??1, ceramide, COL1 and hyaluronan were significantly increased in UA group(100, 200 and 400mg/kg/day) compared to vehicle control. The mRNA expression of HAS isoform(HAS1, HAS2, HAS3), COL1A1, COL1A2, and TGF-??1 were also significantly increased by UA.
Conclusions : UA has skin moisturizing effects and enhancement activities in skin function related components(COL1, hyaluronan, ceramide and TGF-??1). These results suggested that UA can be a developing candidate for developing alternative skin protective agent or functional food ingredient.
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KEYWORD
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Unripe apple, Skin hydration, Skin moisturizing, Skin aging
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